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Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme that facilitates redox reactions in cellular metabolism and serves as a substrate for enzymes regulating DNA repair, gene expression, and aging, with declining levels linked to metabolic and neurodegenerative disorders.
Store in a cool, dark place or freeze at -20°C for long term storage. Refrigerate after reconstitution
Product Name: NAD+
CAS Number: 53-84-9
Molecular Formula: C21H27N7O14P2
Molecular Weight: 663.43 g/mol
Nicotinamide adenine dinucleotide (NAD+) is a critical coenzyme found in all living cells, with the molecular formula C₂₁H₂₇N₇O₁₄P₂, functioning as an essential mediator in redox reactions and cellular metabolism. It exists in oxidized (NAD+) and reduced (NADH) forms, playing a pivotal role in energy production by facilitating electron transfer in metabolic pathways such as glycolysis, the citric acid cycle, and oxidative phosphorylation. Beyond its redox functions, NAD+ is a substrate for enzymes like sirtuins, poly(ADP-ribose) polymerases (PARPs), and CD38, which regulate DNA repair, gene expression, and cellular signaling, impacting aging, stress responses, and genomic stability. NAD+ levels decline with age, contributing to metabolic and neurodegenerative disorders, prompting research into NAD+ precursors like nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) to boost its levels. Its broad physiological roles make NAD+ a key target for therapeutic interventions in aging, metabolic diseases, and neurodegenerative conditions, though optimal supplementation strategies and long-term effects remain under investigation.
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