Tesa/Ipa 11mg/6mg

Ipamorelin (also known as NNC-26-0161) is a synthetic pentapeptide (5 amino acids long) designed as a selective ghrelin mimetic and growth hormone secretagogue receptor (GHSR) ligand, featuring non-natural amino acids including α-aminoisobutyric acid (Aib) at the N-terminus, D-2-naphthylalanine (D-2-Nal), and D-phenylalanine for enhanced stability and receptor specificity, with C-terminal amidation.

Its amino acid sequence is: Aib-His-D-2-Nal-D-Phe-Lys-NH₂ (or H-Aib-His-D-2Nal-D-Phe-Lys-NH₂).

Chemically, it has the molecular formula C₃₈H₄₉N₉O₅ and a molar mass of approximately 711.85–711.87 g/mol (CAS 170851-70-4). This oligopeptide is classified as a research chemical and is commonly utilized in laboratory investigations of GHSR-mediated pathways, peptide-receptor interactions, and related biochemical processes

Tesamorelin is a synthetic analog of growth hormone–releasing hormone (GHRH) investigated for its interaction with the GHRH receptor and subsequent modulation of intracellular signaling associated with the GH/IGF-1 axis. Its structure incorporates an N-terminal trans-3-hexenoyl modification designed to enhance peptide stability while retaining the 44-amino-acid sequence responsible for receptor recognition and signaling activity. Research involving tesamorelin examines receptor-binding characteristics, pituitary somatotroph signaling, peptide stability, endocrine biomarker dynamics, and downstream metabolic pathways under controlled experimental conditions. Its amino-acid sequence is Y-A-D-A-I-F-T-N-S-Y-R-K-V-L-G-Q-L-S-A-R-K-L-L-Q-D-I-M-S-R-Q-Q-G-E-S-N-Q-E-R-G-A-R-A-R-L, with the complete modified structure represented as trans-3-hexenoyl-Y-A-D-A-I-F-T-N-S-Y-R-K-V-L-G-Q-L-S-A-R-K-L-L-Q-D-I-M-S-R-Q-Q-G-E-S-N-Q-E-R-G-A-R-A-R-L.