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Tesamorelin ( TH-9507, or N-[trans-4-hydroxycyclohexylcarbonyl]-Tesamorelin) is a synthetic hexacosapeptide (26 amino acids long) analogue of growth hormone-releasing hormone (GHRH), featuring an N-terminal trans-4-hydroxycyclohexylcarbonyl modification for increased stability against dipeptidyl peptidase IV (DPP-IV) cleavage, along with substitutions at positions 8 (Gln), 15 (Ala), and 27 (Leu) relative to native GHRH to enhance enzymatic resistance and receptor affinity.
Product Name: Tesa
CAS: 901758-09-6
Molecular Mass: 5136 g/mol
Molecular Formula: C221H366N72O67S
PubChem ID: 483927426
Tesamorelin ( TH-9507, or N-[trans-4-hydroxycyclohexylcarbonyl]-Tesamorelin) is a synthetic hexacosapeptide (26 amino acids long) analogue of growth hormone-releasing hormone (GHRH), featuring an N-terminal trans-4-hydroxycyclohexylcarbonyl modification for increased stability against dipeptidyl peptidase IV (DPP-IV) cleavage, along with substitutions at positions 8 (Gln), 15 (Ala), and 27 (Leu) relative to native GHRH to enhance enzymatic resistance and receptor affinity.
Its amino acid sequence is: trans-4-OH-cyclohexylcarbonyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH₂ (with C-terminal amidation).
Chemically, it has the molecular formula C₂₂₁H₃₆₆N₆₆O₇₈S and a molar mass of approximately 5135.89 g/mol (CAS 218949-78-5). This oligopeptide is classified as a research chemical and is commonly utilized in laboratory investigations of GHRH-related receptor pathways, peptide pharmacokinetics, and endocrine biochemistry
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