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Cagrilintide (also known as 0833) is a synthetic, long-acting acylated peptide analogue of human amylin, consisting of 37 amino acids with targeted sequence modifications and N-terminal lipidation via a γ-glutamyl-linked eicosanedioic acid (C20 diacid) fatty chain for enhanced stability and pharmacokinetic properties. Its primary sequence incorporates substitutions such as Asn14Glu and Val17Arg for improved solubility and helix stabilization via salt bridge formation, multiple proline insertions (e.g., at positions 25, 28, 29) to reduce β-sheet propensity and amyloid fibril formation, and a C-terminal proline amidation; it features a disulfide bridge between Cys³ and Cys⁸.
Product Name: Cagrilintide
CAS: 1415456-99-3
Molecular Mass: 4409.01 g/mol
Molecular Formula: C194H312N54O59S2
PubChem ID: 171397054
Cagrilintide (also known as 0833) is a synthetic, long-acting acylated peptide analogue of human amylin, consisting of 37 amino acids with targeted sequence modifications and N-terminal lipidation via a γ-glutamyl-linked eicosanedioic acid (C20 diacid) fatty chain for enhanced stability and pharmacokinetic properties. Its primary sequence incorporates substitutions such as Asn14Glu and Val17Arg for improved solubility and helix stabilization via salt bridge formation, multiple proline insertions (e.g., at positions 25, 28, 29) to reduce β-sheet propensity and amyloid fibril formation, and a C-terminal proline amidation; it features a disulfide bridge between Cys³ and Cys⁸.
The full abbreviated sequence is: {Eicosanedioic acid-γ-Glu}-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Glu-Phe-Leu-Arg-His-Ser-Ser-Asn-Asn-Phe-Gly-Pro-Ile-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Pro-NH₂ (Disulfide bridge: Cys³–Cys⁸).
Chemically, it has the molecular formula C₁₉₄H₃₁₂N₅₄O₅₉S₂ and a molar mass of approximately 4409.01 g/mol (CAS 1415456-99-3).
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