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PT-141 is a synthetic cyclic heptapeptide and non-selective melanocortin receptor agonist (primarily MC3R/MC4R), centrally activates hypothalamic pathways producing erectogenic effects and increased solicitational behaviors independent of vascular mechanisms—while modulating dopamine and other neurotransmitters
Name: PT-141
CAS Number: 189691-06-3
Molecular Formula: C₅₀H₆₈N₁₄O₁₀
Molecular Mass 1025.2 g/mol
PubChem CID: 9941379
PT-141 is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH). It functions as a non-selective agonist at melanocortin receptors, with principal activity at MC3R and MC4R, which are expressed in various regions of the central nervous system, including the hypothalamus.
The compound activates central melanocortinergic pathways. MC4R, in particular, is enriched in nuclei involved in autonomic and neuroendocrine regulation, such as the paraventricular nucleus, arcuate nucleus, and medial preoptic area. PT-141 administration modulates neurotransmitter release, including increased dopamine efflux in hypothalamic and limbic regions, mediated in part by presynaptic MC4R activation. The compound operates independently of peripheral vascular mechanisms, with its primary site of action located within the central nervous system.
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