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Melanotan II (also known as MT-II or Melanotan-II) is a synthetic cyclic heptapeptide (7 amino acids long) designed as an analogue of alpha-melanocyte-stimulating hormone (α-MSH), featuring N-terminal acetylation, substitution of norleucine (Nle) for methionine at position 4, D-phenylalanine at position 7, and a lactam bridge (cyclization) between the side chains of Asp⁵ and Lys¹⁰ for enhanced structural stability and receptor binding affinity.
Product Name: Melanotan 2
CAS: 121062-08-6
Molecular Mass: 1024.18 g/mol
Molecular Formula: C₅₀H₆₉N₁₅O₉
PubChem ID: 92432
Melanotan II (also known as MT-II or Melanotan-II) is a synthetic cyclic heptapeptide (7 amino acids long) designed as an analogue of alpha-melanocyte-stimulating hormone (α-MSH), featuring N-terminal acetylation, substitution of norleucine (Nle) for methionine at position 4, D-phenylalanine at position 7, and a lactam bridge (cyclization) between the side chains of Asp⁵ and Lys¹⁰ for enhanced structural stability and receptor binding affinity.
Its amino acid sequence is: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ (with the cyclic (2→7)-lactam bridge between Asp and Lys, and C-terminal amidation).
Chemically, it has the molecular formula C₅₀H₆₉N₁₅O₉ and a molar mass of approximately 1024.18 g/mol (CAS 121062-08-6). This oligopeptide is classified as a research chemical and is commonly utilized in laboratory investigations of melanocortin receptor pathways, peptide cyclization chemistry, and related biochemical processes
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