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Tesamorelin is a synthetic 44-amino acid GHRH analog that stimulates pituitary growth hormone release to reduce visceral fat in HIV-associated lipodystrophy, enhancing lipid profiles and body composition via increased IGF-1 levels.
Store in a cool, dark place or freeze at -20°C for long term storage. Refrigerate after reconstitution
Product Name: Tesa
CAS: 901758-09-6
Molecular Mass: 5136 g/mol
Molecular Formula: C221H366N72O67S
PubChem ID: 483927426
Tesamorelin is a synthetic 44-amino acid peptide analog of growth hormone-releasing hormone (GHRH), with the sequence trans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2, designed to stimulate the pituitary gland to release growth hormone (GH). It features a trans-3-hexenoyl group at the N-terminus to enhance stability and half-life compared to native GHRH. Tesamorelin binds to GHRH receptors, increasing endogenous GH secretion, which subsequently elevates insulin-like growth factor-1 (IGF-1) levels, promoting lipolysis and reducing visceral adipose tissue. Administered via subcutaneous injection, it is FDA-approved for reducing excess abdominal fat in HIV-infected patients with lipodystrophy. Its mechanism involves pulsatile GH release, improving lipid profiles and body composition, though long-term effects on cardiovascular risk and glucose metabolism require further study, and side effects may include injection site reactions and mild IGF-1-related adverse events.
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