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$70.00
Glutathione (GSH), a tripeptide (γ-L-glutamyl-L-cysteinylglycine), is a vital endogenous antioxidant that neutralizes reactive oxygen species, detoxifies xenobiotics, and regulates cellular redox homeostasis, immune function, and signaling, with depletion linked to aging and disease.
Store in a cool, dark place or freeze at -20°C for long term storage. Refrigerate after reconstitution
CAS Number:70-18-8
Molecular Formula: C₁₀H₁₇N₃O₆S
Molecular Weight: 307.32 g/mol
PubChem ID: 124886
Glutathione (GSH) is a tripeptide composed of glutamic acid, cysteine, and glycine (γ-L-glutamyl-L-cysteinylglycine), with the molecular formula C₁₀H₁₇N₃O₆S, serving as a critical endogenous antioxidant and detoxifying agent in all eukaryotic cells. It exists in reduced (GSH) and oxidized (GSSG) forms, with the GSH/GSSG ratio maintaining cellular redox homeostasis by neutralizing reactive oxygen species (ROS) and reactive nitrogen species (RNS) through its thiol group, thus protecting against oxidative stress-induced damage to proteins, lipids, and DNA. Glutathione functions as a cofactor for glutathione peroxidases and transferases, facilitating the reduction of peroxides and the conjugation of xenobiotics for detoxification, primarily in the liver. It also plays roles in immune function, gene expression, and cellular signaling via redox-sensitive pathways, including NF-κB and Nrf2. Depletion of GSH is implicated in aging, neurodegenerative diseases, and metabolic disorders, prompting research into supplementation with precursors like N-acetylcysteine (NAC), though bioavailability challenges and variable clinical outcomes necessitate further investigation into optimal therapeutic strategies.
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