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ARA-290 is an 11-amino acid peptide derived from the helix B surface domain of erythropoietin (EPO), engineered to selectively interact with the innate repair receptor (IRR), a heteromeric complex comprising the EPO receptor and the β-common receptor (CD131), without engaging the EPO receptor homodimer responsible for erythropoiesis.
Name: ARA-290
CAS Number: 1208243-50-8
Molecular Formula: C₅₁H₈₄N₁₆O₂₁
Molecular Mass (monoisotopic/average): 1257.3 g/mol
PubChem ID (CID): 91810664
ARA-290 (also known as Cibinetide, PHBSP, or pyroglutamate helix B surface peptide) is a synthetic undecapeptide (11 amino acids long) engineered as a non-erythropoietic analogue derived from the helix B surface region of erythropoietin (EPO), featuring an N-terminal pyroglutamic acid (Pyr or pGlu) residue for stability and a linear sequence without cyclic structures, disulfide bridges, or other post-translational modifications beyond the pyroglutamyl cyclization.
Its amino acid sequence is: Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (or {Glp}-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser; single-letter code: pGlu-EQ L E R A L N S S, with free C-terminus).
Chemically, it has the molecular formula C₅₁H₈₄N₁₆O₂₁ and a molar mass of approximately 1257.3 g/mol (CAS 1208243-50-8). This oligopeptide is classified as a research chemical and is commonly utilized in laboratory investigations of peptide-receptor interactions
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