Epitalon is a synthetic tetrapeptide that activates telomerase to extend telomeres, delays cellular senescence, and prolongs lifespan in animal models, while showing antioxidant and gene-modulating effects, though human efficacy and safety remain unconfirmed by large-scale clinical trials.
Store in a cool, dark place or freeze at -20°C for long term storage. Refredgerate after reconstitution
Product Name: Epitalon
CAS:307297-39-8
Molecular Mass:390.35 g/mol
Molecular Formula:C₁₄H₂₂N₄O₉
PubChem ID:219042
Epitalon (also known as Epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal gland’s epithalamin extract, designed to mimic the activity of the endogenous peptide epithalamin, which regulates melatonin production and circadian rhythms. Preclinical studies in rodents and cell cultures demonstrate that epitalon extends telomere length by activating telomerase enzyme (hTERT), thereby delaying replicative senescence, reducing chromosomal aberrations, and prolonging lifespan in models of accelerated aging (e.g., senescence-accelerated mice, where it increased mean lifespan by 12–15%). It also exhibits antioxidant effects, suppresses lipid peroxidation, and modulates gene expression related to pineal function, immune response, and oncogenesis suppression in vitro and in vivo. While human clinical data remain limited to small-scale Russian trials reporting improved melatonin profiles and reduced age-related morbidity, rigorous randomized controlled trials are lacking, and its long-term safety and efficacy in humans are not established by international regulatory standards.
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